In March 2013, Holland and co-authors published a paper in PLoS One regarding microRNA in HIV genomes, titled 'Identification of Human MicroRNA-Like Sequences Embedded within the Protein-Encoding Genes of the Human Immunodeficiency Virus'. Holland was a doctoral student at the Laboratory of Viral Oncology and Proteomics Research, Keck School of Medicine, where he was supervised by Professor Suraiya Rasheed. In an interview in 1995, Holland said when he turns 40, he would rather be a professor at a university than play music.

Holland is also the co founder of the record label Nitro Records which he operated from 1994 to 2013. Occasionally the band plays ' Gone Away', with only Holland playing the song on piano. Holland sometimes plays the piano during live shows. Holland is one of the two members (along with Noodles) to appear on all of The Offspring's albums, and as of Greg K.'s split from the band in November 2018, he is the only remaining original member left. Their most recent album, Let The Bad Times Roll (2021), was the band's first release on Concord Records. The band then signed with Columbia Records in 1996 (after Brett Gurewitz, owner of Epitaph and guitarist for Bad Religion, sold the contract to Columbia, Holland claims) for whom they released their next six albums, Ixnay on the Hombre (1997), Americana (1998), Conspiracy of One (2000), Splinter (2003), Rise and Fall, Rage and Grace (2008) and Days Go By (2012). Their last album for that label was 1994's Smash, which still holds the world record for most sales of an album on an independent label. Their first release on the label was Ignition, which was released in 1992.

In 1991, the Offspring signed with Epitaph Records (home of Bad Religion, L7, NOFX, Pennywise and other similar bands). This album would eventually be re-issued on November 21, 1995, by Holland's own record label, Nitro Records. After recording a demo in 1988, the Offspring signed a deal with a small-time label, Nemesis Records, for whom they recorded their first full-length album, The Offspring, in March 1989. After some line-up changes, including the addition of Noodles on guitar, Manic Subsidal changed their name to the Offspring in 1985.

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